Biochemical characteristics and fibrinolytic activity of pro-plasminogen activator.
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چکیده
منابع مشابه
Biochemical properties of plasminogen activator inhibitor-1.
PAI-1 is a Mr ~50,000 glycoprotein, which is the primary physiological inhibitor of the two plasminogen activators uPA and tPA. PAI-1 belongs to the serpin protein family. Studies of PAI-1 have contributed significantly to the elucidation of the protease inhibitory mechanism of serpins, which is based on a metastable native state becoming stabilised by insertion of the RCL into the central beta...
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Hepsin, a type II transmembrane serine protease, is strongly up-regulated in prostate cancer. Hepsin overexpression in a mouse prostate cancer model resulted in tumor progression and metastasis, associated with basement membrane disorganization. We investigated whether hepsin enzymatic activity was linked to the basement membrane defects by examining its ability to initiate the plasminogen/plas...
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The fibrinolytic properties of two molecular forms of extrinsic (tissue-type) plasminogen activator, purified from human melanoma cells in culture, were compared. One form, obtained under protection of aprotinin, consisted of a single polypeptide chain with M, = 72,000 while the other form, obtained without aprotinin, consisted of two polypeptide chains with M, = 30,00040,000 each. The two form...
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The observation that aspirin inhibits the increment in tissue plasminogen activator ft-PA) activity induced by venous occlusion of the forearm became controversial with the publication of several nonconfirmatory studies. The current study was performed to confirm the original observation and determine the mechanism by which aspirin suppresses the incremental t-PA activity induced by venous occl...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1986
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.17.365